A novel chimeric protein-based HIV-1 fusion inhibitor targeting gp41 with high potency and stability
نویسندگان
چکیده
A novel chimeric protein-based HIV-1 fusion inhibitor targeting gp41 with high potency and stability Chungen Pan, Lifeng Cai, Hong Lu, Lu Lu, and Shibo Jiang* From Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065 MOE/MOH Key Laboratory of Medical Molecular Virology and Institute of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China The Institute of Human Virology, Key Laboratory of Tropical Disease Control of MOE, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
منابع مشابه
Design of a highly potent HIV-1 fusion inhibitor targeting the gp41 pocket.
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The induction of 2F5- and 4E10-like antibodies broadly neutralising HIV-1 and targeting the membrane external proximal region (MPER) of the transmembrane envelope protein gp41 would be a major advancement for the development of a preventive HIV-1 vaccine, but successful attempts remain rare. Recent studies demonstrated that broadly reactive antibodies develop relatively late during infection an...
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Peptides derived from the C-terminal heptad repeat (CHR) of HIV gp41 have been developed as effective fusion inhibitors against HIV-1, but facing the challenges of enhancing potency and stability. Here, we report a rationally designed novel HIV-1 fusion inhibitor derived from CHR-derived peptide (Trp628~Gln653, named CP), but with an innovative Ile-Asp-Leu tail (IDL) that dramatically increased...
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Induction of broadly neutralizing antibodies (bNAbs) is an important goal for HIV-1 vaccine development. Two autoreactive bNAbs, 2F5 and 4E10, recognize a conserved region on the HIV-1 envelope glycoprotein gp41 adjacent to the viral membrane known as the membrane-proximal external region (MPER). They block viral infection by targeting a fusion-intermediate conformation of gp41, assisted by an ...
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